Structure of PDB 6lzj Chain A

Receptor sequence
>6lzjA (length=245) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
VIESPVDVVKELVENSLDAKATKVEVEIVKGGKRLIRVKDNGTGIHPEDV
EKVVLEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVG
TEVEVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALTNPEVEFTLFSE
GRETLKLKKSSLKERVEEVFQTKTEELYAEGITLRAFVSRNQQGKYYVFI
NKRPIQNKNLKEFLRKVFGKTLVVLYAELPPFFLELVRELAGKEK
3D structure
PDB6lzj A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
ChainA
Resolution1.72836 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A N26 A30 I56 V64 E90 A91 L92 T135 N15 A19 I45 V53 E56 A57 L58 T101
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair
Cellular Component
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lzj, PDBe:6lzj, PDBj:6lzj
PDBsum6lzj
PubMed32571878
UniProtO67518|MUTL_AQUAE DNA mismatch repair protein MutL (Gene Name=mutL)

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