Structure of PDB 6lzi Chain A

Receptor sequence
>6lziA (length=240) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
VIESPVDVVKELVENSLDAKATKVEVEIVKKRLIRVKDNGTGIHPEDVEK
VVEALYSISSVSKFKLRSRFFQEKEGKEIEVEAGNILGTRRVGMPVGTEV
EVRDLFFNLPVRRKFLKKEDTERRKVLELIKEYALTNPEVEFTLFSEGRE
TLKLKKSSLKERVEEVFQTKTEELYAEGITLRAFVSRNQGKYYVFINKRP
IQNKNLKEFLRKVFTLVVLYAELPPFLELVRELAGKEKPI
3D structure
PDB6lzi A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.
ChainA
Resolution1.69106 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N26 A30 I56 E90 A91 L92 T135 N15 A19 I43 E53 A54 L55 T98
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair
Cellular Component
GO:0032300 mismatch repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lzi, PDBe:6lzi, PDBj:6lzi
PDBsum6lzi
PubMed32571878
UniProtO67518|MUTL_AQUAE DNA mismatch repair protein MutL (Gene Name=mutL)

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