Structure of PDB 6lym Chain A

Receptor sequence

>6lymA (length=1281) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

GSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPL
NDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKATDIAHN
CGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAE
KLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQEAFTKL
GRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIKNTFET
TPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMKVETHN
HPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQ
PWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVN
SHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIG
LDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMPE
LVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFD
ELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTR
DVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGARTVTGMV
ARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASARL
AVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEEL
CPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRHT
LTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQLK
GFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAALGD
DHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRF
VITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKANDTD
PGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFHRAG
FDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSILFNH
RVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNHSDR
FEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAALES
KGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHPERV
FRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 6lym Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase.
• Chain: A
• Resolution: 2.46 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	V333 T386 G387 Y388 K649 L652 Q668 P676 A678 N722	V336 T389 G390 Y391 K635 L638 Q654 P662 A664 N708
BS02	MG	A	D679 N722 D884	D665 N708 D870

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6lym, PDBe:6lym, PDBj:6lym
• PDBsum: 6lym
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)