Structure of PDB 6lyk Chain A

Receptor sequence

>6lykA (length=1293) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

ASGLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHF
ADLNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSK
ATDIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVF
SSLTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYL
QEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKM
IKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHIL
MKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNL
RIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFR
TYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLG
GPAMNIGLGGGDLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHD
VGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYV
LAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPL
DVLLGKTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFL
VTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAP
VALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAG
LYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVI
SAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGD
KPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGH
CGVQVDIAALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCV
HYLGQALAGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCA
DQEHEAKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNS
HVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGA
GEGWAKSILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSE
LWPRFVRNHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVE
VRDDAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENG
RVTIMMPHPEAVFRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 6lyk Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	T386 G387 Y388 K649 L652 Q668 P676 A678 N722	T396 G397 Y398 K647 L650 Q666 P674 A676 N720
BS02	GLN	A	G1092 G1093 F1094 D1098 C1135 N1136 Q1139 S1195 H1196 G1197 E1198 H1260	G1090 G1091 F1092 D1096 C1133 N1134 Q1137 S1193 H1194 G1195 E1196 H1258
BS03	MG	A	D679 N722 D884	D677 N720 D882

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6lyk, PDBe:6lyk, PDBj:6lyk
• PDBsum: 6lyk
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)