Structure of PDB 6lxj Chain A

Receptor sequence

>6lxjA (length=388) Species: 1481987 (Influenza A virus (A/Anhui/1-BALF_RG44/2013(H7N9)))

RNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRF
YALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSS
TSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESEC
VCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSC
YGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPND
PNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPN
ALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGR
PKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL

3D structure

• PDB: 6lxj Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus.
• Chain: A
• Resolution: 2.903 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D151 E278 R293 R368 Y402
• Catalytic site (residue number reindexed from 1): D70 E197 R212 R290 Y324
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	A	I388 G390	I310 G312
BS02	MAN	A	D330 P387	D250 P309
BS03	MAN	A	R327 N329 D330 R361 I363	R247 N249 D250 R283 I285
BS04	CA	A	D294 G298 D324 N344A	D213 G217 D244 N266

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:6lxj, PDBe:6lxj, PDBj:6lxj
• PDBsum: 6lxj
• PubMed: 33024040
• UniProt: A0A024E1X5