Structure of PDB 6lxe Chain A

Receptor sequence
>6lxeA (length=768) Species: 9606 (Homo sapiens) [Search protein sequence]
VWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAK
AIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYP
GEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEG
FSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLF
RDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQIL
LYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVR
IDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHL
LANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIR
SDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHH
LNFGMNPDHARNSLSNCGIRQPINHNERLEFLGDAVVEFLTSVHLYYLFP
SLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHA
MANCFQALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ
EPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLT
LGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAK
VAEELGMQEYAITNDKTKRPVALRTKTLADLLQSFIAALYIDKDLEYVHT
FMNVCFFPRLKEFILNQD
3D structure
PDB6lxe Structural Basis for pri-miRNA Recognition by Drosha.
ChainA
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L987 Y999 F1069 V1077 W1078 P1082 L498 Y510 F580 V588 W589 P593
BS02 peptide A A1113 I1114 G1115 V1116 I1117 L1194 E1235 Y1236 T1239 F1240 R1248 A624 I625 G626 V627 I628 L705 E746 Y747 T750 F751 R759
BS03 ZN A H609 H680 H156 H227
BS04 ZN A C536 H549 H1026 C83 H96 H537
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6lxe, PDBe:6lxe, PDBj:6lxe
PDBsum6lxe
PubMed32220645
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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