Structure of PDB 6lwr Chain A

Receptor sequence
>6lwrA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSS
LQDRHGRTIWFQGDPGPLAP
3D structure
PDB6lwr DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R118 N176 Y263 T278 R117 N175 Y243 T258
BS02 dna A E3 K54 R78 M81 F120 R133 Q168 G175 N176 R277 E2 K53 R77 M80 F119 R132 Q167 G174 N175 R257
BS03 dna A H96 I117 R118 R119 F120 R274 H95 I116 R117 R118 F119 R254
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwr, PDBe:6lwr, PDBj:6lwr
PDBsum6lwr
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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