Structure of PDB 6lwp Chain A

Receptor sequence
>6lwpA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QNPDLLELCHSVPKEVVQLGGRGRGEEDFAAFRAWLRCYGMPGMSSLQDR
HGRTIWFQGDPGPLAP
3D structure
PDB6lwp DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainA
Resolution2.64 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P2 E3 E6 K54 G80 M81 R118 F120 R133 Q168 N176 Y263 R277 T278 P1 E2 E5 K53 G79 M80 R117 F119 R132 Q167 N175 Y239 R253 T254
BS02 dna A R34 H96 I117 R118 R119 F120 R33 H95 I116 R117 R118 F119
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6lwp, PDBe:6lwp, PDBj:6lwp
PDBsum6lwp
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

[Back to BioLiP]