Structure of PDB 6lwi Chain A

Receptor sequence
>6lwiA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
GQGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QPDLLELCHSVPKEVVQLGGRGYGSESGEEDFAAFRAWLRCYGMPGMSSL
QDRHGRTIWFQGDPGPLAP
3D structure
PDB6lwi DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainA
Resolution2.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G2 Q3 E6 K54 M81 R118 F120 Q130 R133 Q168 G175 N176 Y244 Y263 H275 R277 T278 G1 Q2 E5 K53 M80 R117 F119 Q129 R132 Q167 G174 N175 Y223 Y242 H254 R256 T257
BS02 dna A R34 R95 H96 I117 R118 R119 F120 H275 R33 R94 H95 I116 R117 R118 F119 H254
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwi, PDBe:6lwi, PDBj:6lwi
PDBsum6lwi
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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