Structure of PDB 6lvm Chain A

Receptor sequence
>6lvmA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM
LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA
KGNLREFLRARRPPGLDYSEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALF
DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA
NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT
3D structure
PDB6lvm Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D617 R621 N622 D635
Catalytic site (residue number reindexed from 1) D150 R154 N155 D168
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EVR A L478 G479 V486 A506 K508 E525 M529 I539 V555 A558 G561 N622 L624 D635 F636 L19 G20 V27 A47 K49 E66 M70 I80 V96 A99 G102 N155 L157 D168 F169 BindingDB: IC50=2.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6lvm, PDBe:6lvm, PDBj:6lvm
PDBsum6lvm
PubMed32278710
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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