Structure of PDB 6lum Chain A

Receptor sequence
>6lumA (length=539) Species: 1445611 (Mycolicibacterium smegmatis MC2 51) [Search protein sequence]
IQEHRYDVVIVGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGM
CAALANVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMG
MPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNC
VKHDVEFFNEFYALDIALTETPAGPVATGVIAYELATGDIHVFHAKAIVF
ATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDMEFHQFHPTGLAGLG
ILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEG
RGAGVPVYPTCHYVMGGIPTTVNGQVLRDNTNVIPGLYAAGECACVSVHG
ANRLGTNSLLDINVFGRRAGIAAAEYAQNHNFVDMPENPAEMVVGWVGDI
LSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRI
TVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPN
RDDTNYMRHTMAYKQGTDLLSDIRLDYKPVVQTRYEPME
3D structure
PDB6lum Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.
ChainA
Resolution2.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F117 Q241 H243 L253 E256 R259 R287 H354 Y355 R395
Catalytic site (residue number reindexed from 1) F116 Q240 H242 L252 E255 R258 R286 H312 Y313 R353
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G13 G16 T35 K36 S42 H43 T44 A47 G49 A202 T203 G204 D222 H354 Y355 G383 E384 R395 S400 L401 G12 G15 T34 K35 S41 H42 T43 A46 G48 A201 T202 G203 D221 H312 Y313 G341 E342 R353 S358 L359
Gene Ontology
Molecular Function
GO:0000104 succinate dehydrogenase activity
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0008202 steroid metabolic process
GO:0009061 anaerobic respiration
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lum, PDBe:6lum, PDBj:6lum
PDBsum6lum
PubMed32843629
UniProtA0QT08

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