Structure of PDB 6lub Chain A

Receptor sequence
>6lubA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
GEAPNQALLRILKETEFKKIKVLGSGTVYKGLWIPEGEKVKIPVAIKETS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGRAKLLGAAAAEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWM
IDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPDMDDVVDADEYL
I
3D structure
PDB6lub CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation.
ChainA
Resolution2.315 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D837 R841 N842 D855
Catalytic site (residue number reindexed from 1) D135 R139 N140 D153
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EUX A L718 A743 C775 M790 Q791 L792 M793 P794 R841 L844 T854 D855 L23 A45 C73 M88 Q89 L90 M91 P92 R139 L142 T152 D153 MOAD: ic50=0.28nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6lub, PDBe:6lub, PDBj:6lub
PDBsum6lub
PubMed32943545
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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