Structure of PDB 6ltu Chain A

Receptor sequence
>6ltuA (length=1034) Species: 32644 (unidentified) [Search protein sequence]
SMSSAIKSYKSVLRPNERKNQLLKSTIQCLEDGSAFFFKMLQGLFGGITP
EIVRFSTEQEKQQQDIALWCAVNWFRPVSQDSLTHTIASDNLVEKFEEYY
GGTASDAIKQYFSASIGESYYWNDCRQQYYDLCRELGVEVSDLTHDLEIL
CREKCLAVATESNQNNSIISVLFGTGEKEDRSVKLRITKKILEAISNLKE
IPKNVAPIQEIILNVAKATKETFRQVYAGNLGAPSTLEKFIAKDGQKEFD
LKKLQTDLKKVIRGKSKERDWCCQEELRSYVEQNTIQYDLWAWGEMFNKA
HTALKIKSTRNYNFAKQRLEQFKEIQSLNNLLVVKKLNDFFDSEFFSGEE
TYTICVHHLGGKDLSKLYKAWEDDPADPENAIVVLCDDLKNNFKKEPIRN
ILRYIFTIRQECSAQDILAAAKYNQQLDRYKSQKANPSVLGNQGFTWTNA
VILPEKAQRNDRPNSLDLRIWLYLKLRHPDGRWKKHHIPFYDTRFFQEIY
AAGNSPVDTCQFRTPRFGYHLPKLTDQTAIRVNKKHVKAAKTEARIRLAI
QQGTLPVSNLKITEISATINSKGQVRIPVKFDVGRQKGTLQIGDRFCGYD
QNQTASHAYSLWEVVKEGQYHKELGCFVRFISSGDIVSITENRGNQFDQL
SYEGLAYPQYADWRKKASKFVSLWQITKKNKKKEIVTVEAKEKFDAICKY
QPRLYKFNKEYAYLLRDIVRGKSLVELQQIRQEIFRFIEQDCGVTRLGSL
SLSTLETVKAVKGIIYSYFSTALNASKNNPISDEQRKEFDPELFALLEKL
ELIRTRKKKQKVERIANSLIQTCLENNIKFIRGEGDLSTTNNATKKKANS
RSMDWLARGVFNKIRQLAPMHNITLFGCGSLYTSHQDPLVHRNPDKAMKC
RWAAIPVKDIGDWVLRKLSQNLRAKNIGTGEYYHQGVKEFLSHYELQDLE
EELLKWRSDRKSNIPCWVLQNRLAEKLGNKEAVVYIPVRGGRIYFATHKV
ATGAVSIVFDQKQVWVCNADHVAAANIALTVKGI
3D structure
PDB6ltu Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
ChainA
Resolution2.57 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A I5 S7 K9 S10 R13 P14 N15 K18 Y119 K306 S346 E348 R398 R402 R428 K433 N435 P436 N441 Q442 Q457 N459 R461 S464 D466 L467 R468 W470 H486 P488 Y490 D491 T492 R493 R515 L523 T524 D525 A528 I529 R530 V531 K533 K534 H535 V536 K537 A538 K540 R575 T639 E640 N641 R642 N644 Q648 Y651 L654 Y659 W662 Y704 R715 R719 D740 C741 R745 L746 G747 L749 Y765 S766 S769 A774 S775 R805 Q809 E812 R813 N816 T839 N840 N841 K845 N848 S849 M852 Q865 L866 M869 I6 S8 K10 S11 R14 P15 N16 K19 Y120 K307 S347 E349 R399 R403 R429 K434 N436 P437 N442 Q443 Q458 N460 R462 S465 D467 L468 R469 W471 H487 P489 Y491 D492 T493 R494 R516 L524 T525 D526 A529 I530 R531 V532 K534 K535 H536 V537 K538 A539 K541 R576 T640 E641 N642 R643 N645 Q649 Y652 L655 Y660 W663 Y705 R716 R720 D741 C742 R746 L747 G748 L750 Y766 S767 S770 A775 S776 R806 Q810 E813 R814 N817 T840 N841 N842 K846 N849 S850 M853 Q866 L867 M870
BS02 dna A Q163 S169 G173 G175 E176 K177 E178 K183 G231 A232 S234 T235 K238 K264 R268 L289 K484 Q164 S170 G174 G176 E177 K178 E179 K184 G232 A233 S235 T236 K239 K265 R269 L290 K485
BS03 dna A N164 N229 P233 N297 T301 K304 I305 T308 R309 N312 Y351 H357 K394 T445 S565 K677 K680 P779 D782 E800 K807 K844 M852 L855 R857 G858 N165 N230 P234 N298 T302 K305 I306 T309 R310 N313 Y352 H358 K395 T446 S566 K678 K681 P780 D783 E801 K808 K845 M853 L856 R858 G859
BS04 dna A F392 D599 Q602 T603 L836 S837 S879 L880 Y881 S883 H884 G989 F393 D600 Q603 T604 L837 S838 S880 L881 Y882 S884 H885 G990
BS05 MG A D599 N601 D1019 D600 N602 D1020
BS06 MG A D599 E833 D600 E834
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