Structure of PDB 6lsg Chain A

Receptor sequence

>6lsgA (length=463) Species: 39054 (Enterovirus A71)

GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLYEPDEYIKEAALHYANQLKQLDIDTSQMSMEEA
CYGTENLEAIDLHSTAGYPYSALGIKKRDILDSTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLVEGINHTHHVYRNKTYCVLGGMPSGMSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELARTGKE
YGLTMTPADKSPCFNEVNWDNATFLKRGFLPDEQFPFLIHPTMPMKEIHE
SIRWTKDARNTQDHVRSLCLLAWHNGKQEYEKFVSAIRSVPVGKALAIPN
YENLRRNWLELFH

3D structure

• PDB: 6lsg Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.
• Chain: A
• Resolution: 2.14 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P20 S114 T115 Y157 K159 I176 G211 C212 N213 G290 Y327 D413 R416 L420	P20 S114 T115 Y157 K159 I176 G211 C212 N213 G290 Y327 D413 R416 L420
BS02	rna	A	S133 Y327 D329 D330 L375 K376 S401 N410 H414 S417	S133 Y327 D329 D330 L375 K376 S401 N410 H414 S417
BS03	ZN	A	H271 H273 C282	H271 H273 C282

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6lsg, PDBe:6lsg, PDBj:6lsg
• PDBsum: 6lsg
• PubMed: 32451382
• UniProt: E5RPG3