Structure of PDB 6lrz Chain A

Receptor sequence
>6lrzA (length=295) Species: 10090 (Mus musculus) [Search protein sequence]
RGSHMVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGC
VVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGV
GVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVL
NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNC
IYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYV
LGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB6lrz Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EOU A V369 G371 V51 G53 MOAD: Kd=10nM
BS02 EOU A Y334 S363 Y572 F577 Y16 S45 Y254 F259 MOAD: Kd=10nM
BS03 EOU A Y525 Q530 S555 Y572 Y207 Q212 S237 Y254 MOAD: Kd=10nM
External links
PDB RCSB:6lrz, PDBe:6lrz, PDBj:6lrz
PDBsum6lrz
PubMed32672401
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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