Structure of PDB 6lry Chain A

Receptor sequence

>6lryA (length=468) Species: 9606 (Homo sapiens)

SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNG
PNILIASLALGDLLHIVIAIPINVYKLLAEDWPFGAEMCKLVPFIQKASV
GITVLSLCALSIDRYRAVASWSRIKVPKWTAVEIVLIWVVSVVLAVPEAI
GFDIITMDYKGSYLRICLLHPVQKTAFMQFYATAKDWWLFSFYFCLPLAI
TAFFYTLMTCEMLRKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKS
PSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKP
VYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKS
RWYNQTPNRAKRVITTFRTGTWDAYLNDHLKQRREVAKTVFCLVLVFALC
WLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIA
LYLVSKRFKNAFKSALCC

3D structure

• PDB: 6lry Crystal structure of human endothelin ETBreceptor in complex with sarafotoxin S6b.
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	P87 I94 N158 K161 E165 V177 Q181 K182 M245 Y247 K248 L252 I254 L256 L257 P259 K273 W336 L339 R343 K346 Y350 R357 L361 L364 L365 D368 Y369	P2 I9 N73 K76 E80 V92 Q96 K97 M157 Y159 K160 L164 I166 L168 L169 P171 K185 W401 L404 R408 K411 Y415 R422 L426 L429 L430 D433 Y434

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6lry, PDBe:6lry, PDBj:6lry
• PDBsum: 6lry
• PubMed: 32001000
• UniProt: P24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB)