Structure of PDB 6lrj Chain A

Receptor sequence
>6lrjA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLRAVLEKLKLSRDDAAGMVKGVVDHLLLRLKCDSAFRGVGLLNYEHV
KISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFNPLSQFLEGEILSAS
KMLSKFRKIIKEEINDIVIMKRGSPAVTLLIKISVDITLALESKSSWPAS
TQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKFQEETWRLSFSHIEKEIL
NNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYH
VKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPE
FNLFSSNLIDKRSKEFLTKQIEYERNNEFPVF
3D structure
PDB6lrj In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQX A K362 R376 Y436 N482 K179 R189 Y249 N295
BS02 ZN A H390 C397 C404 H203 C210 C217
External links
PDB RCSB:6lrj, PDBe:6lrj, PDBj:6lrj
PDBsum6lrj
PubMed32459092
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

[Back to BioLiP]