Structure of PDB 6lre Chain A

Receptor sequence
>6lreA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDVKGVVDHLLLRLKCDSAFRGVGLLNEHVKISA
PNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKENPLSQFLEGEILSASKM
LSKFRKIIKEEIIMKRPAVTLLIISVDITLALESKSSWPASTQEGLRIQN
WLSAKVRKQLRLKPFYLVPKHAQEETWRLSFSHIEKEILNNHGKSKTCCE
NKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQ
NPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDK
RSKEFLTKQIEYERNNEFPVFD
3D structure
PDB6lre In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C397 C404 H192 C199 C206
BS02 EQL A R376 S434 Y436 R178 S236 Y238
External links
PDB RCSB:6lre, PDBe:6lre, PDBj:6lre
PDBsum6lre
PubMed32459092
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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