Structure of PDB 6lp0 Chain A

Receptor sequence
>6lp0A (length=245) Species: 3673 (Momordica charantia) [Search protein sequence]
DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLM
HLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDAR
RKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGA
LLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQ
LAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRN
3D structure
PDB6lp0 Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs.
ChainA
Resolution1.519 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 AMP A Y93 I94 G132 Y134 I178 E183 R186 N213 Y70 I71 G109 Y111 I155 E160 R163 N190
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function

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Biological Process
External links
PDB RCSB:6lp0, PDBe:6lp0, PDBj:6lp0
PDBsum6lp0
PubMed32653369
UniProtP16094|RIP1_MOMCH Ribosome-inactivating protein momordin I

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