Structure of PDB 6low Chain A

Receptor sequence
>6lowA (length=246) Species: 3673 (Momordica charantia) [Search protein sequence]
DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLM
HLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDAR
RKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGA
LLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQ
LAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRNI
3D structure
PDB6low Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs.
ChainA
Resolution1.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A V92 Y93 I94 G132 N133 Y134 I178 E183 R186 V69 Y70 I71 G109 N110 Y111 I155 E160 R163
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:6low, PDBe:6low, PDBj:6low
PDBsum6low
PubMed32653369
UniProtP16094|RIP1_MOMCH Ribosome-inactivating protein momordin I

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