Structure of PDB 6lo2 Chain A

Receptor sequence

>6lo2A (length=364) Species: 9606 (Homo sapiens) [Search protein sequence]

KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN
AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM
LALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILI
AVCDDASIWRWDRL

3D structure

PDB

6lo2 Structure of EED in complex with EZH2 peptide and cmpd20

Chain

Resolution

2.21 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W103 H104 S105 K106 E107 D109 V112 Y154 S159 H160 P161 R201 L246 L315 G316 D317 L318 L353 F372 W373 Q374 L391 E392 E394 R420	W27 H28 S29 K30 E31 D33 V36 Y78 S83 H84 P85 R125 L170 L239 G240 D241 L242 L277 F296 W297 Q298 L315 E316 E318 R344
BS02	EJU	A	F97 Y148 N194 K211 L240 D310 Y365 R367	F21 Y72 N118 K135 L164 D234 Y289 R291

External links

PDB	RCSB:6lo2, PDBe:6lo2, PDBj:6lo2
PDBsum	6lo2
PubMed
UniProt	O75530\|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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