Structure of PDB 6ljk Chain A

Receptor sequence
>6ljkA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
ARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQ
DLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGR
RVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPA
LSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILE
EVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATN
RFRFHFQGPCGTTLPEALA
3D structure
PDB6ljk Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
ChainA
Resolution1.394 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P35 T36 F37 R38 N108 D110 H125
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R71 Q83 V221 F223 G224 E225 N226 L227 L232 V253 V254 Y255 P256 M259 R38 Q50 V188 F190 G191 E192 N193 L194 L199 V220 V221 Y222 P223 M226
BS02 ZN A C166 C169 C207 C212 C133 C136 C174 C179
BS03 GUA A R71 Y102 R105 I142 H158 R38 Y69 R72 I109 H125
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6ljk, PDBe:6ljk, PDBj:6ljk
PDBsum6ljk
PubMed32163813
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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