Structure of PDB 6ld3 Chain A

Receptor sequence

>6ld3A (length=578) Species: 2043570 (Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)

PNMKIIGNRIERIRSEHAETWFFDENHPYRTWAYHGSYEAPSLINGVVRL
LSKPWDVVTGVTGIAPYGQQRVFKEKVDTRVPDPQEGTRQVMSMVSSWLW
KELGKHKRPRVCTKEEFINKVRSNTAVEAVNDPRFWALVDKEREHHLRGE
CQSCVYNMMGKRSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVE
GLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQME
KGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTY
ALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKR
MAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVP
FCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKS
YAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGEWMTTE
DMLVVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRT
TWAENIKNTVNMVRRIIGDEEKYMDYLS

3D structure

• PDB: 6ld3 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	E439 H443 C448 C451	E142 H146 C151 C154
BS02	ZN	A	H714 C730 C849	H405 C421 C540
BS03	G8O	A	L513 C711 H713 R731 M763 L767 T796 S798 H800 G801 W805	L204 C402 H404 R422 M454 L458 T487 S489 H491 G492 W496
BS04	FB2	A	R739 T796 W797	R430 T487 W488

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6ld3, PDBe:6ld3, PDBj:6ld3
• PDBsum: 6ld3
• PubMed: 32796069
• UniProt: A0A024B7W1|POLG_ZIKVF Genome polyprotein