Structure of PDB 6lcr Chain A

Receptor sequence

>6lcrA (length=1044) Species: 759272 (Thermochaetoides thermophila DSM 1495)

GLNSVPLIVIITVTAIKDAIEDYRRTINAPVHRLSGKARFHKDAWKNLVV
GDFVRIYNDDELPADIIILATSDPDGACYVETKNLDGETNLKVRQALRCG
RTLKHARDCERAQFVIESEPPQPNLYKYNGGIDNLLLRGCHLRNTEWALG
VVVFTGHDTKIMMNAPSKRARIARELNFNVICNFGILLIMCLIAAIANGI
AWGKTDASLAWFEYGSIGGTPALTGFITFWAAVIVFQNLVPISLYISLEI
VRTLQAFFIYSDVGMYYEKIDQPCIPKSWNISDDVGQIEYIFSDKTGTLT
QNVMEFKKATINGQPYGEAYTEAQAGMDRRRGINVEEEAKVIREEIAAAK
VRAIRGLRELHDNPYLHDEDMTFIAPDFVEDLAGKNGPEQQQATEHFMLA
LALCHTVVAEKQPGDPPKMIFKAQSPDEAALVATARDMGFTVLGMSDGGI
NVNVMGKDMHFPVLSIIEFNSSRKRMSTIVRMPDGRILLFCKGADSVIYS
RLKKGEQADMRRETAQHLEMFAVEGLRTLCIAERELSEEEYREWRREHDL
AATALENREEKLEEVADKIERDLTLLGGTAIEDRLQDGVPDTIALLADAG
IKLWVLTGDKVETAINIGFSCNLLNNDMDLLRLQVNESDASTEDDYLQLA
EEQLKTNLERFNMTGDDEELKRARKDHNAPSPTYALVIDGFTLRWVLSDS
LKQKFLLLCKQCKSVLCCRVSPAQKAAVVSMVKNGLDVMTLSIGDGANDV
AMIQEADVGVGIAGEEGRQAVMSSDFAIGQFRFLQRLVLVHGRWSYRRLA
ETISNFFYKNMIWTWSIFWYQCYCNFDIAYIFEYTYILMFNLFFTSVPVI
LMGVLDQDVSDTVSLAVPQLYRRGIERKEWTQTKFWLYMIDGVYQSVMSF
FIPFIFVVLTPTAAGNGLDVSERTRLGAYIAHPAVITINGYILINTYRWD
WLMLLSIVLSDVFIFFWTGVYTATTYSAGFYQAAPQVYQELTFWMCLIVT
PALCLLPRLVVKCIQKQRFPYDVDIIREQANRGDFAAADAAAVA

3D structure

• PDB: 6lcr Structures of a P4-ATPase lipid flippase in lipid bilayers.
• Chain: A
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.1: P-type phospholipid transporter.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ACP	A	D606 K607 T608 F781 K786 R839 G920	D294 K295 T296 F469 K474 R527 G608
BS02	P5S	A	E1113 L1199 Y1200 D1203 Y1206 P1319 R1320 V1323 K1324 Q1327	E801 L887 Y888 D891 Y894 P1007 R1008 V1011 K1012 Q1015

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0005215 transporter activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding
• GO:0090554 phosphatidylcholine floppase activity
• GO:0090555 phosphatidylethanolamine flippase activity
• GO:0090556 phosphatidylserine floppase activity
• GO:0140326 ATPase-coupled intramembrane lipid transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0015914 phospholipid transport
• GO:0045332 phospholipid translocation

Cellular Component

• GO:0005768 endosome
• GO:0005794 Golgi apparatus
• GO:0005802 trans-Golgi network
• GO:0005886 plasma membrane
• GO:0010008 endosome membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6lcr, PDBe:6lcr, PDBj:6lcr
• PDBsum: 6lcr
• PubMed: 32303992
• UniProt: G0S196|ATC5_CHATD Phospholipid-transporting ATPase DNF1 (Gene Name=DNF1)