Structure of PDB 6l72 Chain A

Receptor sequence
>6l72A (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYD
NLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLL
KDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYP
LSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVD
LLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGGGMDFDS
KKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ
3D structure
PDB6l72 Sirtuin 2 protein with H3K18 myristoylated peptide
ChainA
Resolution2.501 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P39 D40 F41 R42 N113 D115 H132
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OMR A G84 A85 G86 T89 D95 F96 R97 F119 L138 Q167 I169 H187 F190 I232 V233 G261 T262 S263 V266 N286 K287 E288 C324 G29 A30 G31 T34 D40 F41 R42 F64 L83 Q112 I114 H132 F135 I177 V178 G206 T207 S208 V211 N231 K232 E233 C263
BS02 ZN A C195 C200 C221 C140 C145 C166
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6l72, PDBe:6l72, PDBj:6l72
PDBsum6l72
PubMed
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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