Structure of PDB 6l6s Chain A

Receptor sequence
>6l6sA (length=207) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
GAQDFVPHTADLAELAAAAGECRGCGLYRDATQAVFGAGGRSARIMMIGE
QPGDKEDLAGLPFVGPAGRLLDRALEAADIDRDALYVTNAVKHFKFTRAA
GGKRRIEKTPSRTEVVACRPWLIAEMTSVEPDVVVLLGATAAKALLGNDF
RVTQHRGEVLHVDDVPGDPALVATVHPSSLLRGPKEERESAFAGLVDDLR
VAADVRP
3D structure
PDB6l6s Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.
ChainA
Resolution2.06426 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 dna A P68 A69 E109 G140 A141 R153 V154 T155 V177 H178 S180 S181 L183 R184 P66 A67 E107 G138 A139 R151 V152 T153 V175 H176 S178 S179 L181 R182
BS02 SF4 A A4 C24 G26 C27 K94 H95 C120 W123 A2 C22 G24 C25 K92 H93 C118 W121
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0097506 deaminated base DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function

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Biological Process
External links
PDB RCSB:6l6s, PDBe:6l6s, PDBj:6l6s
PDBsum6l6s
PubMed33248387
UniProtI7F541

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