Structure of PDB 6l6r Chain A

Receptor sequence
>6l6rA (length=610) Species: 9606 (Homo sapiens) [Search protein sequence]
ADPLLLYANRRDLRLVDATNENATIVVGGLEDAAAVDFVFSHGLIYWSDV
SEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDG
SSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVV
KGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENG
KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPV
EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPK
IERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTD
GTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID
QLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFEL
ISDMKTCIVP
3D structure
PDB6l6r Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N117 D138 Q139 N97 D118 Q119
External links
PDB RCSB:6l6r, PDBe:6l6r, PDBj:6l6r
PDBsum6l6r
PubMed33097721
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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