Structure of PDB 6l63 Chain A

Receptor sequence
>6l63A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPED
LTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDAD
GSCALLSPYVQPVCLPSGLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLE
RCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCELTLQGIISWG
SGCGDRNKPGVYTDVAYYLAWIREHTVS
3D structure
PDB6l63 Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H412 D461 Q560 G561 D562 S563
Catalytic site (residue number reindexed from 1) H40 D89 Q180 G181 D182 S183
Enzyme Commision number 3.4.21.38: coagulation factor XIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W392 S395 H412 Y458 Y515 H538 S541 D557 A558 C559 Q560 G561 S563 S585 W586 G587 S588 W20 S23 H40 Y86 Y135 H158 S161 D177 A178 C179 Q180 G181 S183 S198 W199 G200 S201
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6l63, PDBe:6l63, PDBj:6l63
PDBsum6l63
PubMed32839601
UniProtP00748|FA12_HUMAN Coagulation factor XII (Gene Name=F12)

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