Structure of PDB 6l5n Chain A

Receptor sequence

>6l5nA (length=377) Species: 9606 (Homo sapiens)

SFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGK
TFSFAIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKK
LSVACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHV
VLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVA
KKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIRVYSG
HQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITLKGFRNG
SFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGV
CICFYQHKEEYQLVQVEQKAGIKFKRI

3D structure

• PDB: 6l5n Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
• Chain: A
• Resolution: 2.242 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P268 T269 R270 G294 G295 Y298 T315 G317 R318 D321 F349 Q352 E446 K448 H468 G469 R476 T494	P82 T83 R84 G108 G109 Y112 T129 G131 R132 D135 F163 Q166 E260 K262 H282 G283 R290 T308
BS02	rna	A	R255 P297 G299 F302 R306	R69 P111 G113 F116 R120
BS03	ANP	A	V206 F210 Q213 T232 G233 G235 K236 T237 D502 R527 R530	V20 F24 Q27 T46 G47 G49 K50 T51 D316 R341 R344
BS04	ANP	A	K474 Q475 I478	K288 Q289 I292

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding

External links

• PDB: RCSB:6l5n, PDBe:6l5n, PDBj:6l5n
• PDBsum: 6l5n
• PubMed: 32714761
• UniProt: Q9NR30|DDX21_HUMAN Nucleolar RNA helicase 2 (Gene Name=DDX21)