Structure of PDB 6l3u Chain A

Receptor sequence
>6l3uA (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
CGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEF
VCHTQQPGCKAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIW
HWELSGGAGSLRLLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACR
REPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGLGRWWR
T
3D structure
PDB6l3u Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel.
ChainA
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D66 P70 D65 P69
BS02 CA A R184 E187 R164 E167
Gene Ontology
Molecular Function
GO:0005243 gap junction channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process
GO:0007154 cell communication
GO:0007267 cell-cell signaling
GO:0007605 sensory perception of sound
GO:0042552 myelination
GO:0055085 transmembrane transport
GO:0086053 AV node cell to bundle of His cell communication by electrical coupling
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexin complex
GO:0043209 myelin sheath

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Cellular Component
External links
PDB RCSB:6l3u, PDBe:6l3u, PDBj:6l3u
PDBsum6l3u
PubMed32923625
UniProtQ8NFK1|CXG3_HUMAN Gap junction gamma-3 protein (Gene Name=GJC3)

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