Structure of PDB 6l36 Chain A

Receptor sequence
>6l36A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM
AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFAN
LDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRK
PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKK
TESDAALHPLLQEIYRDMY
3D structure
PDB6l36 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution3.301 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW9 A C276 T279 M330 V332 C77 T80 M131 V133
BS02 GW9 A E251 L254 C275 A333 Y334 E52 L55 C76 A134 Y135
BS03 GW9 A K257 N261 H274 C275 C278 L456 H457 P458 K58 N62 H75 C76 C79 L257 H258 P259
BS04 F5A A Q277 S280 Y314 I354 H440 V444 I447 K448 A454 A455 L456 Y464 Q78 S81 Y115 I155 H241 V245 I248 K249 A255 A256 L257 Y265 BindingDB: EC50=30000nM,IC50=>10000nM,Ki=35000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6l36, PDBe:6l36, PDBj:6l36
PDBsum6l36
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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