Structure of PDB 6l0q Chain A

Receptor sequence

>6l0qA (length=382) Species: 272557 (Aeropyrum pernix K1)

ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALY
VIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVR
SRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADA
TSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAP
STVHLLPRVMKDSKNEGFVHVNQYYNDANFEAHMRGTAREIFVQSRRGGL
ALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVET
GMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAK
KAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE

3D structure

• PDB: 6l0q Identification of amino acid residues important for recognition of O-phospho-l-serine substrates by cysteine synthase.
• Chain: A
• Resolution: 1.58 Å

Enzymatic activity

• Enzyme Commision number: 2.5.1.47: cysteine synthase.
  2.5.1.65: O-phosphoserine sulfhydrylase.
  4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	E1U	A	T152 S153 N155 F156 T203 Q224 Y225 G261 T262 S263 H265 G295 S341 P368	T151 S152 N154 F155 T202 Q223 Y224 G260 T261 S262 H264 G294 S340 P367

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity
• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016829 lyase activity
• GO:0033847 O-phosphoserine sulfhydrylase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0019344 cysteine biosynthetic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6l0q, PDBe:6l0q, PDBj:6l0q
• PDBsum: 6l0q
• PubMed: 33563496
• UniProt: Q9YBL2|CYSO_AERPE Protein CysO (Gene Name=cysO)