Structure of PDB 6l03 Chain A

Receptor sequence
>6l03A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPG
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQ
GPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPAYGVPSS
AASLIDFLRVVRNQQSLAVSNMPEPPIVVHASAGIGRTGTFCSLDICLAQ
LEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMV
3D structure
PDB6l03 PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
ChainA
Resolution2.084 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y333 D335 Y471 A515 S516 A517 I519 G520 R521 Q559 Y57 D59 Y195 A231 S232 A233 I235 G236 R237 Q275
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6l03, PDBe:6l03, PDBj:6l03
PDBsum6l03
PubMed33764618
UniProtP43378|PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (Gene Name=PTPN9)

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