Structure of PDB 6kzx Chain A

Receptor sequence
>6kzxA (length=198) Species: 562 (Escherichia coli) [Search protein sequence]
SSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHC
KEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHLHGVGVS
VVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWP
SLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYE
3D structure
PDB6kzx Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E0L A N46 E50 V71 D73 R76 I78 P79 T165 N40 E44 V65 D67 R70 I72 P73 T144 MOAD: ic50=0.2uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6kzx, PDBe:6kzx, PDBj:6kzx
PDBsum6kzx
PubMed32391502
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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