Structure of PDB 6kzd Chain A

Receptor sequence
>6kzdA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
TYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP
TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK
FLRAHGPDAGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA
NLLVKIGDFGMSRDVYSTDYYRLHTMLPIRWMPPESIMYRKFTTESDVWS
FGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLG
CWQREPQQRLNIKEIYKILHALGKATPIYLDI
3D structure
PDB6kzd Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
ChainA
Resolution1.708 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D679 R683 N684 D697
Catalytic site (residue number reindexed from 1) D140 R144 N145 D158
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DZ6 A A570 K572 E588 L592 V601 F617 Y619 M620 L686 G696 D697 F698 A43 K45 E61 L65 V74 F90 Y92 M93 L147 G157 D158 F159 MOAD: ic50=2.95nM
PDBbind-CN: -logKd/Ki=8.53,IC50=2.95nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kzd, PDBe:6kzd, PDBj:6kzd
PDBsum6kzd
PubMed31271959
UniProtQ16288|NTRK3_HUMAN NT-3 growth factor receptor (Gene Name=NTRK3)

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