Structure of PDB 6ky6 Chain A

Receptor sequence
>6ky6A (length=274) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
MLYKELGRTGEEIPALGLGTWGIGGFETPDYSRDEEMVELLKTAIKMGYT
HIDTAEYYGGGHTEELIGKAIKDFRREDLFIVSKVWPTHLRRDDLLRSLE
NTLKRLDTDYVDLYLIHWPNPEIPLEETLSAMAEGVRQGLIRYIGVSNFD
RRLLEEAISKSQEPIVCDQVKYNIEDRDPERDGLLEFCQKNGVTLVAYSP
LRRTLLSEKTKRTLEEIAKNHGATIYQIMLAWLLAKPNVVAIPKAGRVEH
LRENLKATEIKLSEEEMKLLDSLG
3D structure
PDB6ky6 Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D53 Y58 K84 H117
Catalytic site (residue number reindexed from 1) D53 Y58 K84 H117
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G19 T20 W21 Y58 H117 N148 Q169 Y198 S199 P200 L201 R203 T204 Y226 I242 P243 K244 G246 H250 E253 N254 G19 T20 W21 Y58 H117 N148 Q169 Y198 S199 P200 L201 R203 T204 Y226 I242 P243 K244 G246 H250 E253 N254
BS02 EPR A Y58 W86 H117 Y58 W86 H117
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6ky6, PDBe:6ky6, PDBj:6ky6
PDBsum6ky6
PubMed31573681
UniProtQ9X265

[Back to BioLiP]