Structure of PDB 6kxy Chain A

Receptor sequence
>6kxyA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
SLAKRIYEAYLKNFNMNKVKARVILSGKNPPFVIHDMETLCMAEKTLVAQ
NKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVY
EAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMK
FNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQS
NHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIY
RDM
3D structure
PDB6kxy Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K292 L302 N303 Q305 V306 L309 P458 L459 E462 K78 L88 N89 Q91 V92 L95 P244 L245 E248
BS02 T06 A I272 F273 C276 Q277 S280 Y314 L344 I354 M355 H440 V444 Y464 I58 F59 C62 Q63 S66 Y100 L130 I140 M141 H226 V230 Y250 BindingDB: EC50=1530nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6kxy, PDBe:6kxy, PDBj:6kxy
PDBsum6kxy
PubMed32376995
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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