Structure of PDB 6kxx Chain A

Receptor sequence
>6kxxA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
SLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTL
VAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLND
QVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDI
MEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGI
VHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDA
ALHPLLQEIYRDM
3D structure
PDB6kxx Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T288 K292 L302 N303 Q305 V306 L309 P458 L459 E462 T84 K88 L98 N99 Q101 V102 L105 P254 L255 E258
BS02 T02 A I272 F273 C276 S280 Y314 I354 M355 H440 Y464 I68 F69 C72 S76 Y110 I150 M151 H236 Y260 BindingDB: EC50=660nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kxx, PDBe:6kxx, PDBj:6kxx
PDBsum6kxx
PubMed32376995
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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