Structure of PDB 6kwr Chain A

Receptor sequence

>6kwrA (length=453) Species: 39054 (Enterovirus A71)

GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDIFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLHEPDEYIKEAALHYANQLKQLEINTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDPTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMAFGHLYEAFHA
NPGTITGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPVNWGNATFLKRGFLPDEQFPFLIHPTMPMREIHESIRWTKDAR
NTQDHVRSLCLLAWHNGKQEYEKFVSTIRSVPVGRALAIPNYENLRRNWL
ELF

3D structure

• PDB: 6kwr A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	N18 P20 K24 S45 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 R277 S289 G290 C291 S292 Y327 R416 L420	N18 P20 K24 S45 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 R277 S289 G290 C291 S292 Y327 R407 L411
BS02	rna	A	Y327 D329 L375 R377 S401 K406 N410 S417	Y327 D329 L366 R368 S392 K397 N401 S408
BS03	ZN	A	H271 H273	H271 H273

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6kwr, PDBe:6kwr, PDBj:6kwr
• PDBsum: 6kwr
• PubMed: 31863580
• UniProt: M4QLY4