Structure of PDB 6kr5 Chain A

Receptor sequence
>6kr5A (length=335) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
NITINTPRKRIYHNILETIGGTPLVELHGVTDHPSIKKNTKILVKLECFN
PMSSVKDRVGFNIIYQAIKDGRLKPGMEIIEATSGNTGIGLCQAGAVFGY
PVNIVMPSTMSVERQMIMKAFGANLVLSDGTKGMPGAIAKYEELIKQHPN
KYFPANQFGNPDNTAAHVYTANEIWEDTNGEVDIIVSAVGTAGTVIGVGE
NLKKKKKGVKVVAVEPAESAVLSGKPKGPHGIQGIGAGFVTDIYKKEVVD
EITPIKTQDAWKMARAVVKYDGIMCGMSSGAAILAGLKEAGKVENEGKTI
VIILPDCGERYLSTDLYKTIEEGTKQQVLDSLLLH
3D structure
PDB6kr5 Crystal structure of O-Acetylserine sulfhydralase (OASS) isoform 3 from Entamoeba histolytica: Pharmacophore-based virtual screening and validation of novel inhibitors.
ChainA
Resolution1.544 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K58 N88 V191 G192 T193 A194 T196 G236 S280 P307 D308 K56 N86 V189 G190 T191 A192 T194 G234 S278 P305 D306
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kr5, PDBe:6kr5, PDBj:6kr5
PDBsum6kr5
PubMed32145643
UniProtQ401L7

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