Structure of PDB 6kr3 Chain A

Receptor sequence
>6kr3A (length=842) Species: 11060 (dengue virus type 2) [Search protein sequence]
TLGEKWKNRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSR
GSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVKEVKGLTKGG
PGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVE
AGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVR
NPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVD
LGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHG
SYETKQTSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDT
RTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSWKSARE
AVEDSGFWELVDKERNLHLEGKCETCVYNMMSRAIWYMWLGARFLEFEAL
GFLNEDHWFSRENSLSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWD
TRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTV
MDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTE
EIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASALTALNDMGKVRK
DIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRAR
ISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVP
TSRTTWTHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLGKRE
DQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPS
3D structure
PDB6kr3 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase.
ChainA
Resolution2.931 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A S56 G81 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 S49 G74 G79 W80 T97 K98 H103 E104 V123 D124 V125 F126 D139
BS02 SAH A L70 N223 L63 N216
BS03 ZN A E438 H442 C447 C450 E414 H418 C423 C426
BS04 ZN A H712 H714 C728 C847 H673 H675 C689 C804
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6kr3, PDBe:6kr3, PDBj:6kr3
PDBsum6kr3
PubMed32357182
UniProtQ91H74

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