Structure of PDB 6kqy Chain A

Receptor sequence
>6kqyA (length=1002) Species: 9606 (Homo sapiens) [Search protein sequence]
TAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMN
GRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKR
EIELYGCPPDFPYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLK
RMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPK
DGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAAT
LRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDN
GVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVP
SDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAV
TICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKT
IQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQT
SQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIES
LSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEA
PFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMW
PEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL
ADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFN
DRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGM
HRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNE
VLIHSSQYLMEVTHDLRLRLKNYPSHCTIYVAKNYPPWQHTTLSVLRKHF
EANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILD
LQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLN
VF
3D structure
PDB6kqy Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LEU A Y52 P53 Y54 H91 H251 H681 Y46 P47 Y48 H85 H208 H638
BS02 LEU A T293 L294 R295 K384 S396 K464 T250 L251 R252 K341 S353 K421
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0006429 leucyl-tRNA aminoacylation
GO:0008361 regulation of cell size
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to L-leucine
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
GO:1904263 positive regulation of TORC1 signaling
GO:1990253 cellular response to leucine starvation
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016604 nuclear body
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kqy, PDBe:6kqy, PDBj:6kqy
PDBsum6kqy
PubMed33910001
UniProtQ9P2J5|SYLC_HUMAN Leucine--tRNA ligase, cytoplasmic (Gene Name=LARS1)

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