Structure of PDB 6kqp Chain A

Receptor sequence

>6kqpA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]

DKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECIN
RMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIK
KGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKG
NYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL
GNGKTVCKCGAPNCSGFLGV

3D structure

PDB

6kqp Covalent inhibition of NSD1 histone methyltransferase.

Chain

Resolution

2.4 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SAM	A	R1952 W1954 T1994 N1995 F1996 Y1997 R2017 N2020 H2021 Y2058 N2065 C2070 K2071 L2081	R89 W91 T131 N132 F133 Y134 R154 N157 H158 Y195 N202 C207 K208 L218
BS02	ZN	A	C2023 C2070 C2072 C2077	C160 C207 C209 C214
BS03	ZN	A	C1905 C1920 C1925 C1931	C42 C57 C62 C68
BS04	ZN	A	C1895 C1897 C1905 C1911	C32 C34 C42 C48

Gene Ontology

	Molecular Function
GO:0042054	histone methyltransferase activity

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:6kqp, PDBe:6kqp, PDBj:6kqp
PDBsum	6kqp
PubMed	32868895
UniProt	Q96L73\|NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=NSD1)

[Back to BioLiP]