Structure of PDB 6knv Chain A

Receptor sequence
>6knvA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIKVDLE
AFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRA
AVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDD
TEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVHFW
PKLLMKVTDLRMIGACHASWFCPTELFPPLFLEVF
3D structure
PDB6knv Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 K306 L454 E457 K71 K89 L230 E233
BS02 8HO A F269 F272 I275 I276 R282 M313 R316 A317 L330 N331 W438 F52 F55 I58 I59 R65 M96 R99 A100 L113 N114 W220
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6knv, PDBe:6knv, PDBj:6knv
PDBsum6knv
PubMed31655060
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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