Structure of PDB 6knu Chain A

Receptor sequence
>6knuA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIDDLEA
FSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAA
VRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT
EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFW
PKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB6knu Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K288 E299 I302 E457 K70 E81 I84 E239
BS02 8HO A F272 I276 A279 R282 M313 S314 R316 A317 L330 L346 F54 I58 A61 R64 M95 S96 R98 A99 L112 L128
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6knu, PDBe:6knu, PDBj:6knu
PDBsum6knu
PubMed31655060
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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