Structure of PDB 6klh Chain A

Receptor sequence
>6klhA (length=1884) [Search protein sequence]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTLTEEQVESFNEIKHDVQVALAKMADVSLHEVKDFDPD
VLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLKNLTTSSYVDEE
YFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSISSNSGNLKFGL
SYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFER
AICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKI
DLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFFHQTMQLNGQIP
SHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQ
ITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFV
MGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTR
ISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDD
KETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSE
QEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQSKLSRQSSVAS
GFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSL
NKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNNQNFFWAVKPKV
VRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFL
DVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSYTDWEL
GLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIE
LAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRISLSDHVRMSTK
FKLKRKMVYSFSLECIMDVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDG
VSVVASLPLFTGQASFDLAAMLIESNLAGSNDSPELSDKYSYRLSGPENQ
EDPLVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSMLHQL
WPYLKATSQVILFQQEDFTIVHDLYKKQLTKSIE
3D structure
PDB6klh Structural insight into arenavirus replication machinery.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N335 G339 D391 S492 L495 K502 T503 S504 Y534 F583 F905 Y1449 G1626 N308 G312 D364 S459 L462 K469 T470 S471 Y495 F544 F822 Y1261 G1410
BS02 MN A D1188 D1330 E1381 D1019 D1149 E1193
BS03 ZN A C284 C470 H472 C272 C437 H439
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6klh, PDBe:6klh, PDBj:6klh
PDBsum6klh
PubMed32214249
UniProtQ6IVU0

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