Structure of PDB 6kld Chain A

Receptor sequence
>6kldA (length=1617) [Search protein sequence]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTGLTQEELSLMYEALTEEQVESFNEIKHDVQVALAKMA
DSPFGVMKEIRAEVSLHEVKDFDPDVLPPEVYKELCDAVYKSSEKCNFFL
EGVLDVCPLGLLLKNLTTSSYVDEEYFMCFKYLLIQGHFDQFTNAALRNL
CFYSEDSPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRL
VEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGP
TMSPALFLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAE
AYCIGSTSLSEEFFHQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLIT
EQFLCYALDLLYDVIPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSS
KLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPT
QLSETIDTICDQCIANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQ
DVKDWVDGSRGYRLQRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEE
NLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLR
TKLMTVPTLIKTLQSKLSRQSSVASGFIGFCKSMGSKCVRDGGFLYIKEV
YSGVSACTCEICALKPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACEL
GEWVFSTVKEPQNNQNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLF
DEHLTPFMNDLQVSRTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDN
SVYIVKQSDCALAHIRQ
3D structure
PDB6kld Structural insight into arenavirus replication machinery.
ChainA
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D1188 E1381 D1044 E1218
BS02 ZN A C284 C470 H472 C272 C437 H439
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kld, PDBe:6kld, PDBj:6kld
PDBsum6kld
PubMed32214249
UniProtQ6IVU0

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