Structure of PDB 6kla Chain A

Receptor sequence
>6klaA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
EVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKV
VEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNI
VNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSEDDELALDLEDLLSF
SYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSN
YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG
MPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ
LIEKQISES
3D structure
PDB6kla Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
ChainA
Resolution2.109 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D792 R796 N797 D810
Catalytic site (residue number reindexed from 1) D170 R174 N175 D188
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DJX A T670 Y672 C673 G676 L799 D810 F811 T117 Y119 C120 G123 L177 D188 F189 PDBbind-CN: -logKd/Ki=7.25,IC50=56nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6kla, PDBe:6kla, PDBj:6kla
PDBsum6kla
PubMed31721578
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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