Structure of PDB 6kiy Chain A

Receptor sequence

>6kiyA (length=275) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]

SMLYKELGRTGEEIPALGLGTWGIGGFETPDYSRDEEMVELLKTAIKMGY
THIDTAEYYGGGHTEELIGKAIKDFRREDLFIVSKVWPTHLRRDDLLRSL
ENTLKRLDTDYVDLYLIHWPNPEIPLEETLSAMAEGVRQGLIRYIGVSNF
DRRLLEEAISKSQEPIVCDQVKYNIEDRDPERDGLLEFCQKNGVTLVAYS
PLRRTLLSEKTKRTLEEIAKNHGATIYQIMLAWLLAKPNVVAIPKAGRVE
HLRENLKATEIKLSEEEMKLLDSLG

3D structure

PDB

6kiy Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima.

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G19 T20 W21 Y58 H117 N148 Q169 Y198 S199 P200 L201 R203 T204 Y226 I242 P243 K244 G246 R247 H250 E253 N254	G20 T21 W22 Y59 H118 N149 Q170 Y199 S200 P201 L202 R204 T205 Y227 I243 P244 K245 G247 R248 H251 E254 N255
BS02	EPR	A	W21 Y58 W86 H117 R203	W22 Y59 W87 H118 R204

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:6kiy, PDBe:6kiy, PDBj:6kiy
PDBsum	6kiy
PubMed	31573681
UniProt	Q9X265

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