Structure of PDB 6kid Chain A

Receptor sequence
>6kidA (length=1004) Species: 9606 (Homo sapiens) [Search protein sequence]
TAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMN
GRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKR
EIELYGCPPDFPSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQD
LKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYS
PKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVA
ATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTK
DNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTS
VPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLS
AVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVK
KTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKK
QTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLI
ESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFK
EAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVA
MWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRL
ALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPAST
FNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVE
GMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPV
NEVLIHSSQYLMEVTHDLRLRLKNYPSHCTIYVAKNYPPWQHTTLSVLRK
HFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRI
LDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKP
LNVF
3D structure
PDB6kid Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A F50 P51 Y52 P53 Y54 G62 H63 S66 S673 G674 D676 L677 H709 L710 F44 P45 Y46 P47 Y48 G56 H57 S60 S632 G633 D635 L636 H668 L669
BS02 LEU A T293 T390 S396 D399 Y468 T252 T349 S355 D358 Y427
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004819 glutamine-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006425 glutaminyl-tRNA aminoacylation
GO:0006429 leucyl-tRNA aminoacylation
GO:0008361 regulation of cell size
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to L-leucine
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
GO:1904263 positive regulation of TORC1 signaling
GO:1990253 cellular response to leucine starvation
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0012505 endomembrane system
GO:0016604 nuclear body
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kid, PDBe:6kid, PDBj:6kid
PDBsum6kid
PubMed33910001
UniProtQ9P2J5|SYLC_HUMAN Leucine--tRNA ligase, cytoplasmic (Gene Name=LARS1)

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